News about clinical trials: events, facts and developments on tafs uz.
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The National Medical Research Center named after Meshalkin has developed a drug based on ethyl and isobutyl alcohols for treating arrhythmias. Preclinical trials have been completed, the first phase of clinical research is provisionally scheduled for mid-November, and market entry is possible in 2029–2030.
Otabek YusupovDipiaron, a capsule drug developed at the Volgograd State Medical University, has passed the first phase of clinical trials. In July, the Ministry of Health authorized the second phase involving 308 patients. The drug acts on the GPR119 receptor and, according to the developers, preserved pancreatic cells in animal experiments. If the research is successful, the drug could reach the market no earlier than 2028.
Aziz KarimovIn a clinical trial involving more than 1,100 patients, the personalized mRNA vaccine Intismeran in combination with the immunotherapy Keytruda reduced the risk of death or melanoma recurrence by 42%, and the risk of spread by 38% over two years. MSD and Moderna are preparing to file for registration. Experts call the result important but demand long-term follow-up.
Javlon TursunovA clinical trial called AD-SMART has begun in the UK — a platform study testing several repurposed drugs simultaneously. The first to be tested are metformin (for type 2 diabetes) and atomoxetine (for ADHD). Around 1,200 participants with mild and moderate Alzheimer's disease are planned to be enrolled at more than 30 sites; results for the first drugs are expected by 2030.
Javlon Tursunov
